Real Madrid's worst nightmare was confirmed on Friday when they were drawn in the quarter-finals of the Champions League against bogey side Atletico.
Carlo Ancelotti's men may be the defending champions – a title earned by beating Atleti 4-1 in last season's final – but they have failed to beat their city rivals in six attempts this season across La Liga, the Copa del Rey and Spanish Supercopa. The most recent clash ended 4-0 in Atletico's favour.
Madrid will get another chance to record a victory when they meet in the first leg at the Vicente Calderon on April 14. The return at the Bernabeu takes place eight days later.
Barcelona will resume hostilities with Paris Saint-Germain after being the first two clubs out of the pot in Nyon.
The pair met in the group stage with the French champions inflicting a 3-2 defeat on Barca before Luis Enrique's men extracted a degree of revenge by winning 3-1 at Camp Nou.
Of the three favourites to claim the trophy in Berlin on June 6, Bayern Munich will be the happiest with Friday's outcome.
Pep Guardiola's men were drawn against Porto, conquerors of Basel in the last round, with midfielder Thomas Muller admitting the draw "could have been worse".
Juventus will also fancy their chances of progressing having been paired with Monaco. The principality side survived a second-leg pummelling by Arsenal to scrape into the last eight and will take on a Juve side which is not only running away with Serie A but also proved much too strong for Borussia Dortmund in the last 16.
